Pub. Date : 2012 Nov 8
PMID : 22984865
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Herein, we describe the discovery of a novel class of BACE-1 inhibitors represented by sulfamide 14g, using a medicinal chemistry strategy to optimize central nervous system (CNS) penetration by minimizing hydrogen bond donors (HBDs) and reducing P-glycoprotein (P-gp) mediated efflux. | fusarubin | beta-site APP cleaving enzyme 1 | Mus musculus |