Title : Synthesis and preclinical evaluation of the radiolabeled P-glycoprotein inhibitor [(11)C]MC113.

Pub. Date : 2012 Nov

PMID : 22981987






1 Functional Relationships(s)
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1 Half-maximum effect concentrations (IC(50)) for inhibition of Pgp-mediated rhodamine 123 efflux from CCRFvcr1000 cells were 375+-60nM for MC113 versus 8.5+-2.5nM for tariquidar. Rhodamines phosphoglycolate phosphatase Mus musculus