Title : Oleoyl-L-carnitine inhibits glycine transport by GlyT2.

Pub. Date : 2013 Feb

PMID : 22978602






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Oleoyl-L-carnitine inhibits glycine transport by GlyT2. Glycine glycoprotein alpha-galactosyltransferase 1 (inactive) Homo sapiens
2 BACKGROUND AND PURPOSE: Concentrations of extracellular glycine in the CNS are regulated by two Na(+)/Cl(-) -dependent glycine transporters, GlyT1 and GlyT2. Glycine glycoprotein alpha-galactosyltransferase 1 (inactive) Homo sapiens
3 KEY RESULTS: Oleoyl-L-carnitine inhibited glycine transport by GlyT2, with an IC(50) of 340 nM, which is 15-fold more potent than the previously identified lipid inhibitor N-arachidonyl-glycine. Glycine glycoprotein alpha-galactosyltransferase 1 (inactive) Homo sapiens