Title : Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation.

Pub. Date : 2012 Oct 26

PMID : 22977252






2 Functional Relationships(s)
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1 Up-regulation of SHP by metformin-mediated activation of the ATM-AMP-activated protein kinase pathway led to inhibition of GH-mediated induction of hepatic gluconeogenesis, which was abolished by an ATM inhibitor, KU-55933. Metformin nuclear receptor subfamily 0, group B, member 2 Mus musculus
2 GH-induced hepatic gluconeogenesis was decreased by either metformin or Ad-SHP, whereas the inhibition by metformin was abolished by SHP knockdown. Metformin nuclear receptor subfamily 0, group B, member 2 Mus musculus