Pub. Date : 2012 Sep 13
PMID : 22973882
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons. | Ceramides | tumor necrosis factor | Homo sapiens |
| 2 | Using lipidomics mass spectrometry we confirmed that TNF treatment not only promotes generation of ceramide, but also leads to accumulation of several atypical deoxy-sphingoid bases (DSBs). | Ceramides | tumor necrosis factor | Homo sapiens |
| 3 | CONCLUSIONS: We conclude that TNF/TNFR1-dependent activation of SMases generates ceramide and sphingolipid species that promote degeneration and caspase-dependent cell death of DA neurons. | Ceramides | tumor necrosis factor | Homo sapiens |