Pub. Date : 2012 Dec
PMID : 22972308
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Minocycline and fluorocitrate suppress spinal nociceptive signaling in intrathecal IL-1beta-induced thermal hyperalgesic rats. | fluorocitrate | interleukin 1 beta | Rattus norvegicus |
| 2 | Minocycline, fluorocitrate, or SB203580 pretreatment suppressed this IL-1beta-upregulated P-p38 MAPK mainly in microglia and iNOS mainly in astrocytes; minocycline exhibited the most potent effect. | fluorocitrate | interleukin 1 beta | Rattus norvegicus |
| 3 | Minocycline and fluorocitrate pretreatment abrogated IL-1beta-induced NO release and thermal hyperalgesia in rats. | fluorocitrate | interleukin 1 beta | Rattus norvegicus |
| 4 | In conclusion, minocycline, fluorocitrate, and SB203580 effectively suppressed the IL-1beta-induced central sensitization and hyperalgesia in rats. | fluorocitrate | interleukin 1 beta | Rattus norvegicus |