Pub. Date : 2012 Dec
PMID : 22968630
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NYGGF4 (PID1) effects on insulin resistance are reversed by metformin in 3T3-L1 adipocytes. | Metformin | phosphotyrosine interaction domain containing 1 | Homo sapiens |
| 2 | NYGGF4 (PID1) effects on insulin resistance are reversed by metformin in 3T3-L1 adipocytes. | Metformin | phosphotyrosine interaction domain containing 1 | Homo sapiens |
| 3 | We aimed in the present study to further elucidate the effects of NYGGF4 on IR and the underlying mechanisms through using metformin treatment in 3T3-L1 adipocytes. | Metformin | phosphotyrosine interaction domain containing 1 | Homo sapiens |
| 4 | Our data showed that the metformin pretreatment strikingly enhanced insulin-stimulated glucose uptake through increasing GLUT4 translocation to the PM in NYGGF4 overexpression adipocytes. | Metformin | phosphotyrosine interaction domain containing 1 | Homo sapiens |
| 5 | NYGGF4 overexpression resulted in significant inhibition of tyrosine phosphorylation of IRS-1 and serine phosphorylation of Akt, whereas incubation with metformin strongly activated IRS-1 and Akt phosphorylation in NYGGF4 overexpression adipocytes. | Metformin | phosphotyrosine interaction domain containing 1 | Homo sapiens |
| 6 | The reactive oxygen species (ROS) levels in NYGGF4 overexpression adipocytes were strikingly enhanced, which could be decreased by the metformin pretreatment. | Metformin | phosphotyrosine interaction domain containing 1 | Homo sapiens |
| 7 | Our data also showed that metformin increased the expressions of PGC1-alpha, NRF-1, and TFAM, which were reduced in the NYGGF4 overexpression adipocytes. | Metformin | phosphotyrosine interaction domain containing 1 | Homo sapiens |
| 8 | These results suggest that NYGGF4 plays a role in IR and its effects on IR could be reversed by metformin through activating IRS-1/PI3K/Akt and AMPK-PGC1-alpha pathways. | Metformin | phosphotyrosine interaction domain containing 1 | Homo sapiens |