Title : A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on the APC/β-catenin pathway in the normal mucosa of colorectal adenoma patients.

Pub. Date : 2012 Oct

PMID : 22964475






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In the calcium/vitamin D(3)-supplemented group, beta-catenin decreased 11% (P = 0.20), E-cadherin increased 51% (P = 0.08), and the APC/beta-catenin score increased 16% (P = 0.26). Calcium cadherin 1 Homo sapiens
2 These results support (i) that calcium and vitamin D modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms, (ii) calcium and vitamin D as potential chemopreventive agents against colorectal neoplasms, and (iii) the potential of APC, beta-catenin, and E-cadherin expression as modifiable, preneoplastic risk biomarkers for colorectal neoplasms. Calcium cadherin 1 Homo sapiens
3 These results support (i) that calcium and vitamin D modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms, (ii) calcium and vitamin D as potential chemopreventive agents against colorectal neoplasms, and (iii) the potential of APC, beta-catenin, and E-cadherin expression as modifiable, preneoplastic risk biomarkers for colorectal neoplasms. Calcium cadherin 1 Homo sapiens