Title : Red wine and component flavonoids inhibit UGT2B17 in vitro.

Pub. Date : 2012 Sep 7

PMID : 22958586






2 Functional Relationships(s)
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1 METHODS: Testosterone glucuronidation was assayed using human UGT2B17 supersomes with quantification of unglucuronidated testosterone over time using HPLC with DAD detection. Testosterone UDP glucuronosyltransferase family 2 member B17 Homo sapiens
2 CONCLUSION: This study reports that in an in vitro supersome-based assay, the key steroid-metabolizing enzyme UGT2B17 is inhibited by a number of phenolic dietary substances and therefore may reduce the rate of testosterone glucuronidation in vivo. Testosterone UDP glucuronosyltransferase family 2 member B17 Homo sapiens