Title : Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training.

Pub. Date : 2012 Sep 5

PMID : 22956831






2 Functional Relationships(s)
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1 We have previously shown that chronic treatment with the antibiotic ceftriaxone restores xCT and GLT-1 expression following cocaine self-administration and attenuates both cue- and cocaine-primed reinstatement. Ceftriaxone solute carrier family 1 member 2 Homo sapiens
2 Here we used a (3)H-glutamate uptake assay and microdialysis to test the hypothesis that ceftriaxone restores the function of both GLT-1 and xCT (glutamate reuptake and export, respectively) in the NA core following cocaine self-administration. Ceftriaxone solute carrier family 1 member 2 Homo sapiens