Pub. Date : 2012 Sep 5
PMID : 22956827
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | mPFC infusion of a non-alpha7 nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine blocked the excitatory effect of systemic nicotine on the VTA DA neurons with type-I response, but mPFC infusion of nicotine failed to excite these neurons. | Nicotine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |
| 2 | mPFC infusion of a non-alpha7 nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine blocked the excitatory effect of systemic nicotine on the VTA DA neurons with type-I response, but mPFC infusion of nicotine failed to excite these neurons. | Nicotine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |
| 3 | These results suggest that nAChR activation in the mPFC is necessary, but not sufficient, for systemic nicotine-induced excitation of VTA neurons. | Nicotine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |