Title : The cyclooxygenase and nitric oxide synthesis/pathways mediate the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in long-term diabetic pithed rats.

Pub. Date : 2012

PMID : 22948792






1 Functional Relationships(s)
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1 The inhibitory effect of infusion of alpha-methyl 5-HT (5 microg/kg/min) was abolished in the presence of indomethacin (2 mg/kg), a non-selective cyclooxygenase (COX) inhibitor, or FR 122047 (1.5 mg/kg) or nimesulide (1.5 mg/kg), two selective COX-1 and COX-2 inhibitors, respectively, in long-term-diabetic pithed rats. alpha-methylserotonin cytochrome c oxidase II, mitochondrial Rattus norvegicus