Title : Differential changes in functional activity of organic cation transporters in rats with uranyl nitrate-induced acute renal failure.

Pub. Date : 2012 Aug

PMID : 22941487






3 Functional Relationships(s)
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1 To study the effect of endogenous substrates in plasma from UN-ARF rats on organic cation transport, rOCT- or rOCT2-dependent uptake of tetraethylammonium (TEA) was studied in rOCT1-transfected or rOCT2-transfected LLC-PK1 cells, respectively. Tetraethylammonium solute carrier family 22 member 2 Rattus norvegicus
2 To study the effect of endogenous substrates in plasma from UN-ARF rats on organic cation transport, rOCT- or rOCT2-dependent uptake of tetraethylammonium (TEA) was studied in rOCT1-transfected or rOCT2-transfected LLC-PK1 cells, respectively. Tetraethylammonium solute carrier family 22 member 2 Rattus norvegicus
3 In vitro, the uptake of TEA was decreased significantly by adding UN-ARF plasma, compared with control plasma, in rOCT2-overexpressing LLC-PK1 cells, but not in rOCT1-overexpressing LLC-PK1 cells. Tetraethylammonium solute carrier family 22 member 2 Rattus norvegicus