Title : Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety.

Pub. Date : 2013 Jan 10

PMID : 22940476






2 Functional Relationships(s)
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1 Stratification by SOAs revealed that at 120 ms and 240 ms SOAs in the caffeine condition, PPI was impaired in female ADORA2A 1976TT risk genotype carriers as compared to male ADORA2A 1976TT homozygotes, while no significant effects were observed in the ADORA2A 1976CC/CT non-risk genotype or placebo group. Caffeine adenosine A2a receptor Homo sapiens
2 The present results point to an impaired ability to selectively process very early information and to gate irrelevant sensory information, respectively, in female ADORA2A 1976TT homozygotes in response to caffeine, providing further evidence for the adenosinergic system to be involved in the pathogenesis of anxiety. Caffeine adenosine A2a receptor Homo sapiens