Title : Altered redox state and apoptosis in the pathogenesis of systemic lupus erythematosus.

Pub. Date : 2013 Apr

PMID : 22940256






2 Functional Relationships(s)
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1 Significant low levels of intracellular glutathione, total thiol and altered redox state (GSH/GSSG) were found in SLE patients, in which lymphocyte apoptosis and activated caspase-3 expression in the lymphocytes were remarkably increased. Glutathione caspase 3 Homo sapiens
2 The lymphocyte apoptosis and activated caspase-3 expression were negatively associated with intracellular levels of GSH and redox state and positively associated with the elevated levels of multiple oxidative stress markers; ROS and lipid peroxidation measured as malondialdehyde (MDA). Glutathione caspase 3 Homo sapiens