Pub. Date : 2012 Oct 1
PMID : 22933628
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus. | pristane | interferon regulatory factor 5 | Mus musculus |
| 2 | In the present study, we examined the mechanisms by which loss of Irf5 protects mice from pristane-induced lupus at early time points of disease development. | pristane | interferon regulatory factor 5 | Mus musculus |
| 3 | Chemotaxis assays using peritoneal lavage from pristane-injected Irf5(+/+) and Irf5(-/-) littermates support an intrinsic defect in Irf5(-/-) monocytes. | pristane | interferon regulatory factor 5 | Mus musculus |
| 4 | Bone marrow reconstitution experiments further supported an intrinsic defect in Irf5(-/-) monocytes because Irf5(+/+) monocytes were preferentially recruited to the peritoneal cavity in response to pristane. | pristane | interferon regulatory factor 5 | Mus musculus |
| 5 | Taken together, these findings demonstrate an intrinsic role for IRF5 in the response of monocytes to pristane and their recruitment to the primary site of inflammation that is thought to trigger lupus onset in this experimental model of SLE. | pristane | interferon regulatory factor 5 | Mus musculus |