Title : Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.

Pub. Date : 2012 Dec

PMID : 22930711






1 Functional Relationships(s)
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1 By using a hybrid beta(2)-adrenergic receptor-C-X-C chemokine receptor type 4 structure as a template, we created a homology model for EBI2 and optimized the docking of 7alpha,25-OHC into the putative ligand binding site, so that the hydroxyl groups interact with residues Arg87, Asn114, and Glu183. 25-hydroxycholesterol G protein-coupled receptor 183 Homo sapiens