Title : Generation of affinity for antithrombin III by supplemental sulfation of heparin species with low affinity for the protein.

Pub. Date : 1990 Oct

PMID : 2292586






2 Functional Relationships(s)
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1 Affinity chromatography of the sulfated products on antithrombin III-Sepharose gel indicated that the polysaccharide acquired some affinity for the protein following the sulfation, as shown by the increase in the proportion of the high-affinity heparin fraction (%) from 1.1 to 6.7. Polysaccharides serpin family C member 1 Homo sapiens
2 Biological examination of these products indicated that sulfation at natural positions along with the polysaccharide chain resulted in significant increases in all the activities (blood anti-clotting, anti-Factor IIa, and anti-Factor Xa), and in the strength of intrinsic fluorescence of antithrombin III. Polysaccharides serpin family C member 1 Homo sapiens