Title : PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition.

Pub. Date : 2012 Nov

PMID : 22915752






1 Functional Relationships(s)
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1 Overexpression of an active form of MEK1 resulted in ERK activation and downregulation of BRCA1, whereas the MEK inhibitor AZD6244 increased BRCA1/2 expression and reversed the effects of MEK1. AZD 6244 mitogen-activated protein kinase kinase 1 Homo sapiens