Title : Possible interaction of cholinergic and GABAergic systems between MS and CA1 upon memory acquisition in rats.

Pub. Date : 2012 Dec 1

PMID : 22909986






5 Functional Relationships(s)
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1 The results showed that pre-training intra-MS/CA1 administration of nonselective muscarinic Ach antagonist, scopolamine (0.5, 1 and 2 mug/rat) and GABA(A) receptor agonist, muscimol (0.01 and 0.02 mug/rat) impaired, while acetylcholinesterase inhibitor, physostigmine (0.5 and 1 mug/rat) and GABA(A) receptor antagonist, bicuculline (0.25 mug/rat) improved memory acquisition. Muscimol carbonic anhydrase 1 Rattus norvegicus
2 Moreover, intra-CA1/MS administration of a subthreshold dose of muscimol or bicuculline increased and reversed the impairment induced by scopolamine in MS/CA1 respectively (cross injection). Muscimol carbonic anhydrase 1 Rattus norvegicus
3 Moreover, intra-CA1/MS administration of a subthreshold dose of muscimol or bicuculline increased and reversed the impairment induced by scopolamine in MS/CA1 respectively (cross injection). Muscimol carbonic anhydrase 1 Rattus norvegicus
4 Also, the result revealed that, intra-CA1/MS administration subthreshold dose of muscimol reduced improvement of memory induced by physostigmine in the MS/CA1, respectively (cross injection). Muscimol carbonic anhydrase 1 Rattus norvegicus
5 Also, the result revealed that, intra-CA1/MS administration subthreshold dose of muscimol reduced improvement of memory induced by physostigmine in the MS/CA1, respectively (cross injection). Muscimol carbonic anhydrase 1 Rattus norvegicus