Title : Low molecular weight heparin inhibits plasma thrombin generation via direct targeting of factor IXa: contribution of the serpin-independent mechanism.

Pub. Date : 2012 Oct

PMID : 22905983






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The molecular target for LMWH/ssLMWH was confirmed by supplementing FIX/antithrombin-depleted plasma with 90 nm recombinant FIX possessing mutations in the heparin-binding exosite. Heparin, Low-Molecular-Weight serpin family C member 1 Homo sapiens
2 CONCLUSIONS: Therapeutic LMWH concentrations inhibit plasma thrombin generation via antithrombin-independent interaction with the FIXa heparin-binding exosite. Heparin, Low-Molecular-Weight serpin family C member 1 Homo sapiens