Title : How immune complexes from certain IgG NAbs and any F(ab')₂ can mediate excessive complement activation.

Pub. Date : 2012

PMID : 22903675






1 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Unlike IgG-IC F(ab")2-IC are not cleared by Fc-receptor dependent processes and circulate long enough to form secondary IC with anti-hinge NAbs that rigidify the complexes such that they capture dimeric C3b and gain the potency to stimulate complement amplification. nabs complement C3 Homo sapiens