Pub. Date : 2012 Nov
PMID : 22899752
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic nicotine administration increases alpha4beta2 neuronal nicotinic acetylcholine receptor (nAChR) density in brain. | Nicotine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |
| 2 | We used a newly developed method involving radioligand binding to measure the concentrations and nAChR occupancy of saz-A, nicotine, and varenicline in brains from chronically treated rats. | Nicotine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |
| 3 | These findings reinforce a model of nicotine addiction based on desensitization of up-regulated nAChRs and introduce a potential new strategy for smoking cessation therapy in which drugs such as saz-A can promote smoking cessation without maintaining nAChR up-regulation, thereby potentially increasing the rate of long-term abstinence from nicotine. | Nicotine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |