Title : Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.

Pub. Date : 2012 Sep 1

PMID : 22895185






2 Functional Relationships(s)
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1 To further investigate the mechanisms underlying these effects, we examined the impact of DACi on the transcription factor c-MYC and the Polycomb group protein BMI1, which are induced by LAFP and involved in leukemic transformation. daci MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 In AML1/ETO or PLZF/RARalpha-positive 32D cells, DACi-mediated antiproliferative effects were associated with downregulation of BMI1 and c-MYC protein levels. daci MYC proto-oncogene, bHLH transcription factor Homo sapiens