Pub. Date : 2012 Oct 15
PMID : 22892142
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhanced antitumor activity of vitamin C via p53 in cancer cells. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 2 | Because p53 is activated by DNA-damaging stress and then regulates various cellular conditions, we hypothesized that p53 can sensitize cancer cells to ascorbate. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 3 | Because p53 is activated by DNA-damaging stress and then regulates various cellular conditions, we hypothesized that p53 can sensitize cancer cells to ascorbate. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 4 | Using isogenic cancer cells, we observed that the presence of p53 can affect ascorbate cytotoxicity, and also reactivation of p53 can make cancer cells sensitive to ascorbate. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 5 | Using isogenic cancer cells, we observed that the presence of p53 can affect ascorbate cytotoxicity, and also reactivation of p53 can make cancer cells sensitive to ascorbate. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 6 | p53-dependent enhancement of ascorbate cytotoxicity is caused by increased reactive oxygen species generation via a differentially regulated p53 transcriptional network. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 7 | p53-dependent enhancement of ascorbate cytotoxicity is caused by increased reactive oxygen species generation via a differentially regulated p53 transcriptional network. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 8 | We also found that transcriptionally activated p53 was derived from MDM2 ubiquitination by ascorbate and subsequently its signaling network renders cancer cells more susceptible to oxidative stress. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 9 | Similar to the p53 effect on in vitro ascorbate cytotoxicity, inhibition of tumor growth is also stronger in p53-expressing tumors than in p53-deficient ones in vivo. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 10 | Similar to the p53 effect on in vitro ascorbate cytotoxicity, inhibition of tumor growth is also stronger in p53-expressing tumors than in p53-deficient ones in vivo. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 11 | Similar to the p53 effect on in vitro ascorbate cytotoxicity, inhibition of tumor growth is also stronger in p53-expressing tumors than in p53-deficient ones in vivo. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 12 | This is the first observation that ascorbate cytotoxicity is positively related to p53 expression, activating its transcriptional network to worsen intracellular oxidative stress and consequently enhancing its cytotoxicity. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 13 | Based on our study, reactivation of p53 may help to achieve more consistent cytotoxic effects of ascorbate in cancer therapies. | Ascorbic Acid | tumor protein p53 | Homo sapiens |