Title : Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: an implication for the disrupted barrier mechanism in atopic dermatitis.

Pub. Date : 2012 Oct

PMID : 22884781






1 Functional Relationships(s)
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1 In contrast, the addition of Th1 cytokines (GM-CSF/IFN-gamma/TNF-alpha) at concentrations of 2.5 or 10nM resulted in a slight increase in SC ceramide levels, which were accompanied by no change or an increase in the expression of those genes encoding sphingolipid metabolic enzymes in the epidermis. Ceramides tumor necrosis factor Homo sapiens