Title : A new class of selective and potent 7-dehydrocholesterol reductase inhibitors.

Pub. Date : 2012 Sep 13

PMID : 22882119






3 Functional Relationships(s)
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1 In the latter assay panel, several of the compounds were distinguished by a strong and selective inhibition of 7-dehydrocholesterol reductase (7-DHCR, EC 1.3.1.21), an enzyme responsible for the conversion of 7-dehydrocholesterol to cholesterol in the last step of cholesterol biosynthesis. Cholesterol 7-dehydrocholesterol reductase Homo sapiens
2 In the latter assay panel, several of the compounds were distinguished by a strong and selective inhibition of 7-dehydrocholesterol reductase (7-DHCR, EC 1.3.1.21), an enzyme responsible for the conversion of 7-dehydrocholesterol to cholesterol in the last step of cholesterol biosynthesis. Cholesterol 7-dehydrocholesterol reductase Homo sapiens
3 In the latter assay panel, several of the compounds were distinguished by a strong and selective inhibition of 7-dehydrocholesterol reductase (7-DHCR, EC 1.3.1.21), an enzyme responsible for the conversion of 7-dehydrocholesterol to cholesterol in the last step of cholesterol biosynthesis. Cholesterol 7-dehydrocholesterol reductase Homo sapiens