Title : Potential of a γ-glutamyl-transpeptidase-stable glutathione analogue against amyloid-β toxicity.

Pub. Date : 2012 Mar 21

PMID : 22860189






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Psi-GSH fulfilled four cardinal properties of GSH, namely, traversing across the blood brain barrier (BBB) via the GSH active uptake machinery, replacing GSH in the glyoxalase-I mediated detoxification of methylglyoxal, protecting cells against chemical oxidative insult, and finally lowering the cytotoxicity of amyloid-beta peptide. Glutathione glyoxalase I Homo sapiens
2 Psi-GSH fulfilled four cardinal properties of GSH, namely, traversing across the blood brain barrier (BBB) via the GSH active uptake machinery, replacing GSH in the glyoxalase-I mediated detoxification of methylglyoxal, protecting cells against chemical oxidative insult, and finally lowering the cytotoxicity of amyloid-beta peptide. Glutathione glyoxalase I Homo sapiens
3 Psi-GSH fulfilled four cardinal properties of GSH, namely, traversing across the blood brain barrier (BBB) via the GSH active uptake machinery, replacing GSH in the glyoxalase-I mediated detoxification of methylglyoxal, protecting cells against chemical oxidative insult, and finally lowering the cytotoxicity of amyloid-beta peptide. Glutathione glyoxalase I Homo sapiens
4 Psi-GSH fulfilled four cardinal properties of GSH, namely, traversing across the blood brain barrier (BBB) via the GSH active uptake machinery, replacing GSH in the glyoxalase-I mediated detoxification of methylglyoxal, protecting cells against chemical oxidative insult, and finally lowering the cytotoxicity of amyloid-beta peptide. Glutathione glyoxalase I Homo sapiens