Pub. Date : 2014 Jun
PMID : 22859221
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-catenin involvement in arsenite-induced VEGF expression in neuroblastoma SH-SY5Y cells. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 2 | In the present study, we demonstrated that arsenite induced VEGF expression in neuroblastoma SH-SY5Y cells without induction of HIF-1alpha, a well-known transcriptional activator for VEGF suggesting that arsenite-induced VEGF expression in SH-SY5Y cells may not require HIF-1alpha activation. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 3 | We therefore investigated whether beta-catenin was involved in arsenite-induced VEGF expression in SH-SY5Y cells. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 4 | These results suggested that beta-catenin plays a role in arsenite-induced VEGF in SH-SY5Y cells, and the induction of beta-catenin by arsenite is mediated by inhibition of GSK3 without activating its upstream kinase Akt. | arsenite | vascular endothelial growth factor A | Homo sapiens |