Title : An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancer.

Pub. Date : 2012

PMID : 22848731






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 TSA activated a ROS triggered, p53 independent and caspase dependent mitochondria apoptotic cell death pathway that is characterized with increased ratio of Bax to Bcl-xl, mitochondrial membrane potential disruption, cytochrome c release, and subsequent caspase activation and PARP-1 cleavage. ros BCL2 associated X, apoptosis regulator Homo sapiens