Title : Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma.

Pub. Date : 2012

PMID : 22848663






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 HBx-induced S6K1 activation was reversed by IKKbeta inhibitor Bay 11-7082 or silencing IKKbeta expression using siRNA. 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens
2 HBx upregulated cell proliferation and vascular endothelial growth factor (VEGF) production, and these HBx-upregulated phenotypes were abolished by treatment with IKKbeta inhibitor Bay 11-7082 or mTOR inhibitor rapamycin. 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens