Pub. Date : 2012 Nov
PMID : 22847181
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells. | Paclitaxel | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | We found that paclitaxel activated Stat3 in the human lung cancer cell lines PC14PE6AS2 (AS2) and H157, whereas it reduced Stat3 activation in A549 and H460 cells. | Paclitaxel | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | We found that paclitaxel activated Stat3 in the human lung cancer cell lines PC14PE6AS2 (AS2) and H157, whereas it reduced Stat3 activation in A549 and H460 cells. | Paclitaxel | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Silencing high UCP-2 expression with small interfering RNA (siRNA) in A549 and H460 cells restored paclitaxel-induced Stat3 activation. | Paclitaxel | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | In addition, paclitaxel-induced Stat3 activation led to the upregulation of survivin and Mcl-1, which in turn facilitated cell survival. | Paclitaxel | signal transducer and activator of transcription 3 | Homo sapiens |
| 6 | Treatment with paclitaxel activated Stat3 in CL1-5 but not in CL1-0 cells, whereas in CL1-5 cells, the overexpression of UCP-2 with complementary DNA (cDNA) blocked Stat3 activation. | Paclitaxel | signal transducer and activator of transcription 3 | Homo sapiens |
| 7 | Treatment with paclitaxel activated Stat3 in CL1-5 but not in CL1-0 cells, whereas in CL1-5 cells, the overexpression of UCP-2 with complementary DNA (cDNA) blocked Stat3 activation. | Paclitaxel | signal transducer and activator of transcription 3 | Homo sapiens |