Pub. Date : 2012 Aug 24
PMID : 22842456
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562. | Imatinib Mesylate | microRNA 144 | Homo sapiens |
| 2 | In this study, we first found that c-myc expression is upregulated in imatinib resistant K562R cells, which in turn enhances the expression of miR-144/451. | Imatinib Mesylate | microRNA 144 | Homo sapiens |
| 3 | Knockdown of c-myc or restoration of miR-144/451 in the K562R cells sensitizes K562R cells to imatinib therapy. | Imatinib Mesylate | microRNA 144 | Homo sapiens |
| 4 | Our study here reveals an regulatory pathway between myc and miR-144/451 and highlights that targeting either myc or miR-144/451 might be valuable for eliminating the imatinib resistant CML cells. | Imatinib Mesylate | microRNA 144 | Homo sapiens |
| 5 | Our study here reveals an regulatory pathway between myc and miR-144/451 and highlights that targeting either myc or miR-144/451 might be valuable for eliminating the imatinib resistant CML cells. | Imatinib Mesylate | microRNA 144 | Homo sapiens |