Pub. Date : 2012 Dec 8
PMID : 22841563
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Addition of ethanol significantly increased TNF-alpha secretion and depleted mitochondrial coenzyme-Q(10) which is detrimental for cell viability. | Ethanol | tumor necrosis factor | Homo sapiens |
| 2 | But vitamin E (10mM) could partially restore coenzyme-Q(10) and glutathione content with decreased TNF-alpha secretion in ethanol treated cells. | Ethanol | tumor necrosis factor | Homo sapiens |
| 3 | Hence, it is inferred that ethanol induced cytotoxicity in HepG2 cells due to coenzyme-Q(10) depletion and increased TNF-alpha secretion. | Ethanol | tumor necrosis factor | Homo sapiens |