Title : Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming.

Pub. Date : 2012 Apr-Jun

PMID : 22837861






1 Functional Relationships(s)
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1 As a proof of principle, we focused on the TCA cycle, predicting that isocitrate dehydrogenase (IDH) activity would be altered in PAH, and then demonstrating increased IDH activity not only in cultured hPMVEC expressing mutant BMPR2 but also in the serum of PAH patients. Tricarboxylic Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens