Title : Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

Pub. Date : 2012 Jul 25

PMID : 22837538






2 Functional Relationships(s)
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1 At the cellular level, rapamycin decreases the number of myocytes with abnormal desmin accumulation and decreases the amount of desmin in both muscle and cardiac tissue of Lmna(-/-) mice. Sirolimus lamin A Mus musculus
2 In addition, inhibition of mTORC1 signaling with rapamycin improves defective autophagic-mediated degradation in Lmna(-/-) mice. Sirolimus lamin A Mus musculus