Title : MicroRNA-21 modulates the levels of reactive oxygen species by targeting SOD3 and TNF╬▒.

Pub. Date : 2012 Sep 15

PMID : 22836756






1 Functional Relationships(s)
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1 We found that miR-21 inhibited the metabolism of superoxide to hydrogen peroxide, produced either by endogenous basal activities or exposure to ionizing radiation (IR), by directing attenuating SOD3 or by an indirect mechanism that limited TNFa production, thereby reducing SOD2 levels. Superoxides tumor necrosis factor Homo sapiens