Title : Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases.

Pub. Date : 2012

PMID : 22832115






1 Functional Relationships(s)
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1 A c-fos/lipoxygenase pathway inhibitor and antioxidant, nordihydroguaiaretic acid (NDGA) significantly suppressed ADAMTS-4 mRNA induction and activity. Masoprocol Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens