Title : Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma.

Pub. Date : 2012 Sep 1

PMID : 22826317






1 Functional Relationships(s)
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1 In this study, we demonstrate that administration of a specific CD73 inhibitor, adenosine 5"-(alpha,beta-methylene)diphosphate (APCP), to melanoma-bearing mice induced a significant tumor regression by promoting the release of Th1- and Th17-associated cytokines in the tumor microenvironment. alpha,beta-methyleneadenosine 5'-diphosphate negative elongation factor complex member C/D, Th1l Mus musculus