Pub. Date : 2012 Dec
PMID : 22823335
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study we tested the hypothesis that curcumin attenuates maladaptive cardiac repair and improves cardiac function after ischaemia and reperfusion by reducing degradation of extracellular matrix (ECM) and inhibiting synthesis of collagens via TGFbeta/Smad-mediated signalling pathway. | Curcumin | transforming growth factor beta 1 | Homo sapiens |
| 2 | In addition to reducing collagen synthesis and fibrosis in the ischaemic/reperfused myocardium, curcumin significantly down-regulated the expression of TGFbeta1 and phospho-Smad2/3, and up-regulated Smad7 and also increased the population of alpha-smooth muscle actin expressing myofibroblasts within the infarcted myocardium relative to the control. | Curcumin | transforming growth factor beta 1 | Homo sapiens |