Title : LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis.

Pub. Date : 2012 Jul 20

PMID : 22822152






2 Functional Relationships(s)
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1 In mutants of ctns-1 (C. elegans homolog of CTNS), LAAT-1 was required to reduce lysosomal cystine levels and suppress lysosome enlargement by cysteamine, a drug that alleviates cystinosis by converting cystine to a lysine analog. Cystine Lysosomal amino acid transporter 1 Caenorhabditis elegans
2 In mutants of ctns-1 (C. elegans homolog of CTNS), LAAT-1 was required to reduce lysosomal cystine levels and suppress lysosome enlargement by cysteamine, a drug that alleviates cystinosis by converting cystine to a lysine analog. Cystine Lysosomal amino acid transporter 1 Caenorhabditis elegans