Pub. Date : 2013 Feb
PMID : 22815312
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: potential explanation for increased methadone clearance during pregnancy. | Estradiol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | In rodent models and in HepG2 cells, CYP2B enzymes have been shown to be regulated by estradiol. | Estradiol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Because estradiol concentrations increase by ~50-fold during human pregnancy, it was hypothesized that the increasing estradiol concentrations during human pregnancy would result in induction of CYP2B6 activity. | Estradiol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Because estradiol concentrations increase by ~50-fold during human pregnancy, it was hypothesized that the increasing estradiol concentrations during human pregnancy would result in induction of CYP2B6 activity. | Estradiol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | At 100 nM total estradiol, a concentration achievable during the third trimester of pregnancy, CYP2B6 activity was predicted to increase by 1.5-3-fold, based on increased CYP2B6 activity and mRNA. | Estradiol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | At 100 nM total estradiol, a concentration achievable during the third trimester of pregnancy, CYP2B6 activity was predicted to increase by 1.5-3-fold, based on increased CYP2B6 activity and mRNA. | Estradiol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | When the E(max) and EC(50) values were compared with those for carbamazepine and rifampin, estradiol was found to be as potent an inducer of CYP2B6 as rifampin and carbamazepine. | Estradiol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 8 | These data suggest that, during human pregnancy, the increasing estradiol concentrations will result in increased clearance of drugs that have CYP2B6-mediated clearance pathways. | Estradiol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |