Pub. Date : 2012 Sep 15
PMID : 22800508
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In WT mice 4 days after a single intraperitoneal injection with PentaCB (112 mg/kg), serum total T(4) level was significantly decreased along with a decrease in serum T(4)-TTR complex, and the levels of serum total T(4) in the PentaCB-treated WT mice were almost the same to those in PentaCB-untreated (control) TTR-null mice. | 2,4,5,2',5'-pentachlorobiphenyl | transthyretin | Mus musculus |
| 2 | In WT mice 4 days after a single intraperitoneal injection with PentaCB (112 mg/kg), serum total T(4) level was significantly decreased along with a decrease in serum T(4)-TTR complex, and the levels of serum total T(4) in the PentaCB-treated WT mice were almost the same to those in PentaCB-untreated (control) TTR-null mice. | 2,4,5,2',5'-pentachlorobiphenyl | transthyretin | Mus musculus |
| 3 | In addition, a slight decrease in serum total T(4) by PentaCB treatment was observed in TTR-null mice. | 2,4,5,2',5'-pentachlorobiphenyl | transthyretin | Mus musculus |
| 4 | On the other hand, accumulation level of [(125)I]T(4) in the liver, but not in extrahepatic tissues, was strikingly enhanced in the PentaCB-pretreated WT and TTR-null mice. | 2,4,5,2',5'-pentachlorobiphenyl | transthyretin | Mus musculus |
| 5 | The present findings demonstrate that PentaCB-mediated decrease in serum T(4) level occurs mainly through increase in accumulation level of T(4) in the liver and further indicate that the increased accumulation of T(4) in the liver of WT mice is primarily dependent on the PentaCB-mediated inhibition of serum T(4)-TTR complex formation. | 2,4,5,2',5'-pentachlorobiphenyl | transthyretin | Mus musculus |