Title : Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade.

Pub. Date : 2012 Oct 1

PMID : 22771630






1 Functional Relationships(s)
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1 ODQ and KT5823, respective inhibitors of guanylate cyclase and cyclic GMP-dependent kinase (PKG), strongly reversed andrographolide-mediated inhibition of platelet aggregation, relative [Ca(2+)]i mobilization, and IKKbeta, and p65 phosphorylation. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one protein kinase cGMP-dependent 1 Homo sapiens