Title : Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways.

Pub. Date : 2012 Sep

PMID : 22766885






6 Functional Relationships(s)
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1 Toll-like receptor 4 (TLR4) and TLR2 were shown to be activated by saturated fatty acids (SFAs) but inhibited by docosahexaenoic acid (DHA). Fatty Acids toll like receptor 4 Homo sapiens
2 Toll-like receptor 4 (TLR4) and TLR2 were shown to be activated by saturated fatty acids (SFAs) but inhibited by docosahexaenoic acid (DHA). Fatty Acids toll like receptor 4 Homo sapiens
3 Toll-like receptor 4 (TLR4) and TLR2 were shown to be activated by saturated fatty acids (SFAs) but inhibited by docosahexaenoic acid (DHA). Fatty Acids toll like receptor 4 Homo sapiens
4 Toll-like receptor 4 (TLR4) and TLR2 were shown to be activated by saturated fatty acids (SFAs) but inhibited by docosahexaenoic acid (DHA). Fatty Acids toll like receptor 4 Homo sapiens
5 These results and additional studies with the LPS sequester polymixin B and in MyD88(-/-) macrophages indicated that SFA-induced activation of TLR2 or TLR4 is a fatty acid-specific effect, but not due to contaminants in BSA or fatty acid preparations. Fatty Acids toll like receptor 4 Homo sapiens
6 These results and additional studies with the LPS sequester polymixin B and in MyD88(-/-) macrophages indicated that SFA-induced activation of TLR2 or TLR4 is a fatty acid-specific effect, but not due to contaminants in BSA or fatty acid preparations. Fatty Acids toll like receptor 4 Homo sapiens