Pub. Date : 2012 Jul 5
PMID : 22764099
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While investigating the mechanism of Akt inhibition, we found that short-term incubation with these compounds induced rapid shedding of cellular nanovesicles containing EGFR, IGFR and p-Akt that occurred in vitro and in vivo, while prolonged incubation led to cell detachment and death that depended on sphingomyelinase-mediated generation of ceramide. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Similarly, exogenous ceramide also decreased active Akt and induced nanovesicle release. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | These results indicate ceramide generation underlies the Akt inhibition and cytotoxicity of this group of agents, and suggests nanovesicle shedding and uptake might potentially propagate their cytotoxicity in vivo. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |