Title : β-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice.

Pub. Date : 2012

PMID : 22761897






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 beta-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice. Diethylnitrosamine catenin (cadherin associated protein), beta 1 Mus musculus
2 Thus, DEN/PB enhanced HCC in mice lacking beta-catenin in the liver may be due to their ineptness at regulating cell survival, leading to enhanced fibrosis and regeneration through PDGFRalpha activation. Diethylnitrosamine catenin (cadherin associated protein), beta 1 Mus musculus