Pub. Date : 2012 Jul
PMID : 22753722
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Delta-tocotrienol augments cisplatin-induced suppression of non-small cell lung cancer cells via inhibition of the Notch-1 pathway. | tocotrienol, delta | notch receptor 1 | Homo sapiens |
| 2 | Previously, we demonstrated that delta-tocotrienol inhibits NSCLC cell proliferation, invasion and induces apoptosis by down-regulation of the Notch-1 signaling pathway. | tocotrienol, delta | notch receptor 1 | Homo sapiens |
| 3 | These results suggest that down-regulation of Notch-1, via inhibition of NF-kappaB signaling pathways by delta-tocotrienol and cisplatin, in combination, could provide a potential novel approach for tumor arrest in NSCLC, while lowering the effective dose of cisplatin. | tocotrienol, delta | notch receptor 1 | Homo sapiens |