Title : Probing the interaction of cisplatin with cytochrome C by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.

Pub. Date : 2012 Jul 17

PMID : 22746312






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Probing the interaction of cisplatin with cytochrome C by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Cisplatin cytochrome c, somatic Homo sapiens
2 Here, the interaction of cisplatin with cytochrome c was investigated using Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS). Cisplatin cytochrome c, somatic Homo sapiens
3 Multiple binding sites of cisplatin on cytochrome c were directly determined by FTICR MS combined with trypsin digestion without liquid chromatography (LC) separation. Cisplatin cytochrome c, somatic Homo sapiens
4 Four binding sites (Met65, Met80, His18, and His33) for cisplatin on cytochrome c were identified. Cisplatin cytochrome c, somatic Homo sapiens
5 Moreover, hydrogen/deuterium exchange (H/DX) combined with FTICR MS provides the sensitive method to insight the small conformation change of cytochrome c induced by cisplatin. Cisplatin cytochrome c, somatic Homo sapiens