Pub. Date : 2012 Sep 1
PMID : 22744336
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett"s cells. | honokiol | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | In human tumors, honokiol (a polyphenol in herbal teas) has growth-inhibitory and proapoptotic effects associated with suppressed activation of STAT3. | honokiol | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Cells were infected with constitutively active Stat3-C to assess effects of honokiol-induced STAT3 inhibition on apoptosis. | honokiol | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Within 30 min of honokiol treatment, transformed Barrett"s cells decreased expression of phosphorylated STAT3; decreases in Ras activity and phosphorylated ERK1/2 expression were detected at 24 h. Infection with Stat3-C significantly reduced apoptosis after honokiol treatment. | honokiol | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | Within 30 min of honokiol treatment, transformed Barrett"s cells decreased expression of phosphorylated STAT3; decreases in Ras activity and phosphorylated ERK1/2 expression were detected at 24 h. Infection with Stat3-C significantly reduced apoptosis after honokiol treatment. | honokiol | signal transducer and activator of transcription 3 | Homo sapiens |
| 6 | Within 30 min of honokiol treatment, transformed Barrett"s cells decreased expression of phosphorylated STAT3; decreases in Ras activity and phosphorylated ERK1/2 expression were detected at 24 h. Infection with Stat3-C significantly reduced apoptosis after honokiol treatment. | honokiol | signal transducer and activator of transcription 3 | Homo sapiens |
| 7 | Honokiol causes necrosis and apoptosis in transformed Barrett"s and esophageal adenocarcinoma cells, but not in nontransformed Barrett"s cells, and the proapoptotic effects of honokiol are mediated by its inhibition of STAT3 signaling. | honokiol | signal transducer and activator of transcription 3 | Homo sapiens |